Chargers rookie RB Ryan Mathews raced in for a 27-yard touchdown, and you could hear the fantasy world let out a collective, “thanks for nothing,” and all of the general grousing that comes along with a frustrated fantasy enthusiasts.

The Chargers have listed WR Vincent Jackson (calf) as questionable, but the San Diego Union-Tribune is reporting that the receiver is “a go” vs. the Chiefs, (via Twitter).

Brett Favre headlined a list of big-name players who sustained injuries in Week 13.

A big hit just before halftime of Sunday’s game sent Chargers RB Darren Sproles to the locker room early.

As if losing Vincent Jackson to an injury in his season debut wasn’t enough, the Chargers have now lost perhaps their biggest remaining playmaker — Mike Tolbert – to an injury against the Colts.

Mike Tolbert should be a hot name on the fantasy waiver wire heading into Week 3.

The Chargers have lost rookie RB Ryan Mathews early against the Jaguars due to a right ankle injury, and his return has been announced as questionable.

New Broncos QB Tim Tebow brings increased ticket sales. Just not to his own team.

Ryan Mathews will be the first rookie taken in most 2010 fantasy drafts. No doubt about it.

The Chargers backfield will have a new look in 2010, and it could wind up holding one of next season’s top fantasy sleepers.

The San Diego Chargers could be in the market for two running backs after notifying Darren Sproles on Friday they will allow him to become an unrestricted free agent.

Every year, a few players boast about how they will break new ground by running unheard of times in the 40-yard dash. LSU track star and return man Trindon Holliday became the first to do so this year.

The release of LaDainian Tomlinson has the Chargers backfield in a state of limbo from a fantasy perspective.

Here’s a look at some of the bigger injury news and notes and the fantasy implications as we head into Week 4.

Check out my fantasy spin on the news and notes from the most pressing injuries around the league, including LaDainian Tomlinson and Randy Moss.