Jacob Tamme of the Colts could have a big fantasy week against the Texans, one of the worst teams defending against the tight end.

The Colts announced on Friday that TE Dallas Clark will have wrist surgery next week and will go on injured reserve. Obviously a huge blow to the Colts, and to fantasy enthusiasts everywhere.

Fantasy owners are going to be without Austin Collie for several games due to a hand injury.

Fantasy owners who have Dallas Clark need to be looking for alternatives immediately.

With an assist from George Li on the NFL Network research desk, here’s a look at some of the most notable numbers and best performances to come out of Week 4.

Peyton Manning doesn’t go through many weeks of the NFL season without being applauded for his game day heroics. The latest reason to applaud Manning is his display of selflessness.

You all may have your Christmas day, your St. Patrick’s day or your Talk Like a Pirate day — but my favorite holiday occurs when Gil Brandt hands over his fantasy football draft board.

Colts WR Pierre Garcon and TE Dallas Clark will sit out tonight’s contest against the Bills, as noted here on Tuesday. So one of the keys that I will be watching Thursday night is who gets the start at receiver opposite Reggie Wayne.

Colts WR Pierre Garcon and TE Dallas Clark are expected to miss Thursday’s preseason game against the Bills, according to the team’s official Web site. Much ado about nothing or further fuel for the notion that teams coming off Super Bowl losses tend to struggle the following season?

As expected, it was a short day of work for Peyton Manning, who played two series of the Colts’ preseason opener against the 49ers.

Do not have a fantasy football draft in August. Or at least until after the third preseason game at the very earliest. Forgive me if I attempt to beat you over the head with his notion for the rest of the summer, but I feel pretty strongly about this.

What did Colts TE Dallas Clark do on his last free Sunday before training camp? He waved the green flag to start the Brickyard 400 at Indianapolis Motor Speedway.

In the latest “Best in the Biz” rankings, NFL Network analyst Charles Davis rates Tony Gonzalez as the best tight end in the NFL.

Saints QB Drew Brees isn’t under any pressure, and Colts DE Dwight Freeney‘s injured ankle might be slowing him down as the Super Bowl progresses.

Colts tight end Dallas Clark’s domination of safety Roman Harper is putting Saints defensive coordinator Gregg Williams in a quandary when it comes to play-calling.