Maurice Jones-Drew, the NFL’s second-leading rusher, won’t play in the Jaguars’ home game against the Redskins because of a knee injury that kept him out of practice all week.

Jones-Drew has 1,324 rushing yards this season. He was listed as doubtful on Friday’s injury report.

The Jaguars will have WR Mike Sims-Walker, who had been listed as questionable because of an ankle injury.

The Redskins officially made Donovan McNabb their No. 3 QB, meaning John Beck will back up new starter Rex Grossman.

Full inactives list:

Redskins
Donovan McNabb (No. 3 QB)
RB James Davis
S Reed Doughty
RB Andre Brown
S Kareem Moore
C Erik Cook
OT Jammal Brown
LB Brian Orakpo

Jaguars
QB Todd Bouman (No. 3 QB)
RB Maurice Jones-Drew
WR John Matthews
WR Tiquan Underwood
LB Justin Durant
G Justin Smiley
DE Aaron Morgan
DT Nate Collins

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