Giants QB Eli Manning will be without his starting center for the first time since 2006, as Shaun O’Hara has been ruled out vs. the Tennessee Titans.

O’Hara will miss his first game in four years due to an ankle injury. Adam Koets will start in O’Hara’s place.

For the Titans, DE Jacob  Ford will miss the contest, as expected, with a knee injury.

Giants inactives:

WR Ramses Barden

CB Michael Johnson

LB Phillip Dillard

LB Chase Blackburn

C Shaun O’Hara

T William Beatty

WR Duke Calhoun

DT Linval Joseph

Titans inactives:

3^rd QB: Rusty Smith

DB Robert Johnson

S Nick Schommer

LB Rennie Curran

T Mike Otto

G Ryan Durand

DE Jacob Ford

WR Lavelle Hawkins

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